Hiromi Sesaki

OPA1 controls mitochondrial dysfunction-driven liver fibrosis in MASLD

The paper identifies OPA1 as a key regulator of liver fibrosis in MASLD by linking mitochondrial dysfunction to fibrotic responses through mito-DAMP release and hepatic stellate cell activation.

OPA1-dependent mitochondrial remodeling coordinates TCR signaling and metabolic adaptation during iNKT cell differentiation

Mitochondrial fission controls astrocyte morphogenesis and organization in the cortex

This study shows that mitochondrial fission is essential for astrocyte morphogenesis and organization in the cortex, with Drp1 loss causing morphological and functional deficits.

Disruption of Mitochondrial Dynamics and Stasis Leads to Liver Injury and Tumorigenesis

This study shows that disrupting mitochondrial fission (DRP1) leads to liver injury and tumorigenesis, while loss of fusion proteins has less impact, and triple knockout mice show reduced tumor development.

Mitochondrial Fission Regulates Transcription of Ribosomal Protein Genes in Embryonic Hearts

This study shows that mitochondrial fission is essential for embryonic heart development by regulating ribosomal protein gene transcription through an AMPK-SIRT7-GABPB axis.