Author

Pinzhu Huang

Beth Israel Deaconess Medical CenterORCID 0000-0002-8339-9701Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Yury V. PopoviD· 2 shared Aaron HakimiD· 1 shared Adam L. Essene· 1 shared Alex K. ShalekiD· 1 shared Alexander SturmiD· 1 shared Alexandra–Chloé VillaniiD· 1 shared Amit Dipak AminiD· 1 shared Andriy Myloserdnyy· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersGenetics

Yury V. PopovORCID

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2 papers

Recent·Most cited

OPA1 controls mitochondrial dysfunction-driven liver fibrosis in MASLD

Xinting Yu, Pinzhu Huang, Arvo Justice, Aaron Hakim, Yoshiko Nanki, Zaur Abilov, Edward B. O’Neill, Jerry Cruz Rodriguez, Enzo Cabrera, Marla Sagatelian, Chandra Sekhar Uma Shankar, Brenda R. Flam, Kawtar Al Khalloufi, Hiromi Sesaki, 荣世松, Yury V. Popov

The paper identifies OPA1 as a key regulator of liver fibrosis in MASLD by linking mitochondrial dysfunction to fibrotic responses through mito-DAMP release and hepatic stellate cell activation.

bioRxiv · Sep 27, 2026 · PreprintGenetics

A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients

Yered H. Pita-Juárez, Dimitra Karagkouni, Nikolaos Kalavros, Johannes C. Melms, Sebastian Niezen, Toni Marie Delorey, Adam L. Essene, Olga Rachel Brook, Deepti B. Pant, Disha Skelton-Badlani, Pourya Naderi Yeganeh, Pinzhu Huang, Liuliu Pan, TYLER D. HETHER, Tallulah S. Andrews, , Ioannis S. Vlachos

This study creates a single-nucleus and spatial transcriptomic atlas of the COVID-19 liver, revealing cellular and functional disruptions associated with organ damage.

Genome biology · Mar 14, 2025Peer-reviewedGenomics