Role of type I interferon signaling and microglia in the abnormal long term potentiation and object place recognition deficits of male mice with a mutation of the Tuberous Sclerosis 2 gene
Manuel F. López‐Aranda, Gayle M. Boxx, Miranda Phan, Karen Bach, Rochelle Mandanas, Isaiah Herrera, Sunrae E. Taloma, Chirag Thadani, Odilia Lu, Raymond Bui, Shuhan Liu, Nan Li, Yu Zhou, Genhong Cheng, Alcino J. Silva
This study shows that microglia and type I interferon signaling contribute to memory and long-term potentiation deficits in male Tsc2+/- mice, which can be reversed by microglia depletion or interferon receptor manipulation.
Biological Psychiatry Global Open Science · Apr 14, 2022Peer-reviewedNeuroscience