Alcino J. Silva

Miniscope Zero: a fully wireless, single-cell-resolution miniature microscope for imaging neural dynamics in freely behaving animals

Acute rapamycin treatment reveals novel mechanisms of behavioral, physiological, and functional dysfunction in a maternal inflammation mouse model of autism and sensory over-responsivity

The paper investigates acute rapamycin treatment in a maternal inflammation mouse model of autism, showing rapid rescue of behavioral and functional dysfunctions linked to mTOR pathway activation.

Open-source, high performance miniature multiphoton microscopy systems for freely behaving animals

The paper describes an open-source miniature 2-photon microscope for recording calcium dynamics in freely behaving mice during various experimental conditions.

Intercellular Signaling Pathways as Therapeutic Targets for Vascular Dementia Repair

This study identifies intercellular signaling pathways involved in vascular dementia repair and demonstrates therapeutic potential through drug intervention.

A dual-pathway architecture enables chronic stress to disrupt agency and promote habit formation

This study identifies a dual amygdala-striatal pathway architecture by which chronic stress disrupts agency and promotes habit formation in mice.

Miniscope-LFOV: A large field of view, single cell resolution, miniature microscope for wired and wire-free imaging of neural dynamics in freely behaving animals

The paper introduces a miniature microscope for high-resolution neural imaging in freely behaving rats, capable of imaging over 1000 neurons in the hippocampus and 2000 in the cortex.

Aversive experience drives offline ensemble reactivation to link memories across days

This study shows that strong aversive experiences in mice drive offline reactivation of both recent aversive and older neutral memories, linking them across days.

A Locus Coeruleus- dorsal CA1 dopaminergic circuit modulates memory linking

The paper identifies a locus coeruleus-dorsal CA1 dopaminergic circuit that modulates memory linking without affecting memory formation.

CCR5 closes the temporal window for memory linking

This paper shows that delayed CCR5 expression after memory formation limits the temporal window for linking memories by reducing neuronal overlap in mice.

Role of type I interferon signaling and microglia in the abnormal long term potentiation and object place recognition deficits of male mice with a mutation of the Tuberous Sclerosis 2 gene

This study shows that microglia and type I interferon signaling contribute to memory and long-term potentiation deficits in male Tsc2+/- mice, which can be reversed by microglia depletion or interferon receptor manipulation.

A retrograde mechanism coordinates memory allocation across brain regions

The paper shows that memory allocation across brain regions is coordinated through a retrograde mechanism, demonstrated by manipulating memory in the basolateral amygdala and observing effects in the insular cortex.

Compartmentalized dendritic plasticity in the retrosplenial cortex integrates memories across time

The paper shows that dendritic plasticity in the retrosplenial cortex links memories by allocating spine clusters to the same dendritic segments for temporally close memories.

Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats

This study identifies the dorsal premammillary nucleus as a central node in the escape network by showing its role in controlling escape vigor from both innate and conditioned threats in mice and suggesting a similar pathway in humans.

Breakdown of spatial coding and neural synchronization in epilepsy

This study investigates spatial coding and neural synchronization in epilepsy using in vivo calcium imaging and network modeling, finding impaired spatial processing and desynchronized firing in epileptic mice.

A convergent depression vulnerability pathway encoded by emergent spatiotemporal dynamics

The paper identifies a spatiotemporal dynamic network in the brain associated with depression vulnerability using machine learning and LFP data from stressed mice.