Cytoplasmic Switch of ARS2 Isoforms Promotes Nonsense-Mediated mRNA Decay and Arsenic Sensitivity
Monica Mesa-Perez, Phineas T. Hamilton, Alex Miranda, Nicholas I. Brodie, Connor O’Sullivan, Jennifer L. Christie, Bridget C. Ryan, Robert L. Chow, David R. Goodlett, Christopher J. Nelson, Perry L. Howard
The paper shows that alternative splicing of ARS2 generates cytoplasmic isoforms that switch ARS2's function from inhibiting to promoting nonsense-mediated mRNA decay and enhance arsenic stress response.
Nucleic Acids Research · Jan 13, 2022Peer-reviewedMolecular Biology