GeneticsbioRxivPreprint
Loss of Complement Factor D suppresses alternative pathway activation but fails to reduce lipofuscin accumulation in the retinal pigmented epithelium of Abca4-/- mice
Bridget C. Ryan, Kaitlin E. Griffith, Caitlin N Geczi…·Robert L. Chow
The paper investigates the role of the alternative complement pathway in Stargardt disease by analyzing Abca4-/- and Cfd-/- mice, finding that while the pathway drives complement activation, it does not reduce lipofuscin accumulation.
DOI 10.1101/2025.10.25.684461