Author

Bruck Taddese

AstraZeneca (United Kingdom)ORCID 0000-0002-9884-4978Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:protein structure· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:non-human primate· 1 Approach:statistical model· 1

Frequent Co-Authors

Charlotte Mary DeaneiD· 2 shared Alan P. Lewis· 1 shared Alexander BujotzekiD· 1 shared Amy Lin· 1 shared Andrew G. BuchananiD· 1 shared Arnaud Decock· 1 shared Arthur G. Nuccio· 1 shared Catherine QuigleyiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBioinformatics

Charlotte Mary DeaneORCID

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3 papers

Recent·Most cited

GeneticsbioRxivPreprintMar 20, 2025

A systemically delivered AAV-CFTR gene therapy for cystic fibrosis

Lindsey W. Plasschaert, Cian Stutz, Ester Otarola…·Amy Lin

This paper develops a systemic AAV-CFTR gene therapy approach for cystic fibrosis, demonstrating functional CFTR expression and lung transduction in non-human primates.

DOI 10.1101/2025.03.20.642115

non-human primateexperimental assay

BioinformaticsBioinformaticsPeer-reviewedSep 15, 2021

DLAB - Deep learning methods for structure-based virtual screening of antibodies

Constantin Schneider, Andrew G. Buchanan, Bruck Taddese, Charlotte Mary Deane

DLAB uses deep learning to improve antibody-antigen docking and virtual screening by predicting binding and ranking poses for antibody drug candidates.

102 citationstop 1%

protein structuredeep learning

BioinformaticsmAbsPeer-reviewedJan 1, 2021

Ab-Ligity: Identifying sequence-dissimilar antibodies that bind to the same epitope

Wing Ki Wong, Sarah A. Robinson, Alexander Bujotzek…·Charlotte Mary Deane

Ab-Ligity identifies sequence-dissimilar antibodies that bind to the same epitope by analyzing antibody-antigen interfaces, outperforming existing tools in precision and speed.

46 citations

protein structurestatistical model