Author

Aisha Siddiqa

Jinnah Postgraduate Medical CenterORCID 0000-0002-9905-1347Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 5 Research Focus:differential expression· 4 Assay:DNA methylation· 3 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Muhammad Ali MemoniD· 5 shared Sadia AjaziD· 5 shared Saleema Mehboob Ali· 4 shared Sani-e-Zehra ZaidiiD· 4 shared Aiysha AbidiD· 3 shared Shagufta KhaliqiD· 3 shared Sadaf Firasat· 2 shared Rabbia MuneeriD· 1 shared

Activity by Year

2021-2022 · peak 4/yr

Co-Author Collaboration Network

8 top collaborators · 26 mutual co-author links

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5 shared papersGenetic & Genomic Medicine

Muhammad Ali MemonORCID

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5 papers

Recent·Most cited

Genetic & Genomic MedicineFrontiers in GeneticsPeer-reviewedMar 9, 2022

Germline Mutation Analysis in Sporadic Breast Cancer Cases with Clinical Correlations

Sadia Ajaz, Sani-e-Zehra Zaidi, Saleema Mehboob Ali…·Muhammad Ali Memon

The paper analyzes germline mutations in 84 sporadic breast cancer patients from Pakistan, finding 11.9% with mutations in BRCA1, BRCA2, and TP53, mostly truncating variants.

7 citations

humanwhole-exome sequencing

𝕏 PostBluesky

Genetic & Genomic MedicineFrontiers in OncologyPeer-reviewedDec 6, 2021

Absence of Glutathione S-Transferase Theta 1 Gene is Significantly Associated with Breast Cancer Susceptibility in Pakistani Population and Poor Overall Survival in Breast Cancer Patients: A Case-Control and Case Series Analysis

Sadia Ajaz, Sani-e-Zehra Zaidi, Saleema Mehboob Ali…·Shagufta Khaliq

This study finds that the GSTT1-absent genotype is significantly associated with increased breast cancer risk and poorer overall survival in Pakistani patients.

4 citations

humanDNA methylation

𝕏 PostBluesky

Genetic & Genomic MedicineOral OncologyPeer-reviewedSep 9, 2021

Strong and Significant Associations of Single Nucleotide Variants (SNVs) in the Promoter and 3'-Untranslated Region (3'-UTR) of Vascular Endothelial Growth Factor (VEGF) Gene with Head and Neck Cancers

Sadia Ajaz, Rabbia Muneer, Aisha Siddiqa…·Shagufta Khaliq

This study identifies significant associations between VEGF SNVs and head and neck cancer risk and tumor characteristics in a South Asian population.

5 citations

humanDNA methylation

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintMar 30, 2021

E-cadherin Gene Promoter Hyper-methylation in Blood Samples from Breast Cancer Cases

Sadia Ajaz, Sani-e-Zehra Zaidi, Saleema Mehboob Ali…·Muhammad Ali Memon

The paper reports E-cadherin promoter hypermethylation in blood samples from breast cancer patients, indicating its potential role in metastasis and treatment selection.

DOI 10.1101/2021.03.30.21254647

humanDNA methylation

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintMar 13, 2021

Independent and Combined Associations of 677C/T and 1298A/C Polymorphisms in the MTHFR gene with Breast Cancers in a South-Asian Population

Sadia Ajaz, Sani-e-Zehra Zaidi, Saleema Mehboob Ali…·Shagufta Khaliq

The paper analyzes the associations of MTHFR SNPs 677C/T and 1298A/C with breast cancer risk in a South-Asian population, finding significant diplotype effects but no independent SNP associations.

3 citations

humanstatistical model

𝕏 PostBluesky