Intermolecular β-sheet formation guides the interaction between ubiquitin-like modifier FAT10 and adapter protein NUB1L
Charlotte Weiss, Sarah A. Overall, Nicola Catone, Alexander B. Barnes, Annette Aichem, Guinevere Mathies
The paper investigates the interaction between FAT10 and NUB1L using NMR spectroscopy, revealing that FAT10 adopts an intermolecular β-sheet upon binding, which stabilizes it in an unfolded state for proteasomal degradation.
Journal of the American Chemical Society · May 20, 2026Peer-reviewedBiochemistry