Threshold of somatic mosaicism disrupting the brain function
Jintae Kim, Sang Min Park, Hyun Yong Koh, Ara Ko, Hoon‐Chul Kang, Won Seok Chang, Dong Seok Kim, Jeong Ho Lee
This study shows that a low number of mTOR mutant neurons can cause seizures in mice, and similar low levels of mosaicism are found in human patients.
bioRxiv · Dec 30, 2023 · PreprintGenetics