Author

Igor V. Likhachev

Russian Academy of SciencesORCID 0000-0003-0024-4681Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1 Organism:virus· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Igor M. RouzineiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

1 paper

Recent·Most cited

Evolutionary BiologybioRxivPreprintSep 5, 2025

Epistasis detection and fitness valleys in viral evolution

Igor V. Likhachev, Igor M. Rouzine

This paper detects epistatic interactions in viral evolution using synthetic data and applies the method to SARS-CoV-2 sequences, finding evidence of fitness valleys connecting viral variants.

DOI 10.1101/2025.09.05.674565

viruswhole-genome sequencing

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