Author

Sean A. Locke

University of Puerto Rico-MayaguezORCID 0000-0003-0044-8510Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:database / resource· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Alex R. Van DamiD· 1 shared Alfredo Rodriguez RuiziD· 1 shared LAURA V. MARTINEZ APONTEiD· 1 shared Timothy J. ColstoniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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1 shared paperGenomics

Alex R. Van DamORCID

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1 paper

Recent·Most cited

GenomicsbioRxivPreprintJun 15, 2026

The genome of the coffee bean weevil (Araecerus fasciculatus) reveals a cytochrome P450 repertoire as a convergent candidate mechanism of insect-origin caffeine detoxification

LAURA V. MARTINEZ APONTE, Alfredo Rodriguez Ruiz, Sean A. Locke…·Alex R. Van Dam

This paper presents the first functionally annotated genome of the coffee bean weevil, identifying a unique insect-encoded P450 detoxification pathway for caffeine, distinct from bacterial mechanisms.

DOI 10.64898/2026.06.11.731724

whole-genome sequencingstatistical model

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