MicrobiologyProceedings of the National Academy of SciencesPeer-reviewed
Germline Targeted Baboon Apolipoprotein L-1 Protects Mice Against African Trypanosomes
Sara Fresard, Sarah J. Pangburn, Kayla Leiss…·Joseph Verdi
This study generates trypanosome-resistant murine models expressing primate APOL1 proteins to investigate their role in immunity, finding that baboon APOL1 provides partial protection but with limited expression, while a chimeric APOL1 variant shows protection with a fitness cost.
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