Epigenetic deprogramming driven by disruption of CIZ1-RNA nuclear assemblies in early-stage breast cancers
Gabrielle L. Turvey, Ernesto López de Alba, Emma Stewart, Heather Cook, Ahmad Alalti, Richard T. Gawne, Justin Ainscough, Andrew S. Mason, Dawn Coverley
The paper shows that elevated CIZ1 C-terminal anchor domain in early-stage breast cancers disrupts nuclear RNA assemblies, leading to chromatin deprotection and gene expression changes.
The Journal of Cell Biology · Feb 18, 2025Peer-reviewedCell Biology