Richard T. Gawne

HIF-1 activated by PIM1 assembles a pathological transcription complex and regulon that drives JAK2V617F MPN disease

This study identifies that HIF-1 activation by PIM1 in JAK2V617F-MPNs drives non-canonical transcription complex formation and disease progression.

Familial ALS/FTD-associated RNA-Binding deficient TDP-43 mutants cause neuronal and synaptic transcript dysregulation in vitro

This study shows that RNA-binding deficient TDP-43 mutations in cell models disrupt neuronal differentiation and synaptic pathways, affecting transcriptomic profiles and neurite morphology.

Biologically-informed machine learning identifies a new clinically-actionable bladder cancer subgroup characterised by NRF2 overactivity

The paper uses biologically-informed machine learning to identify a new bladder cancer subgroup with NRF2 overactivity, which is clinically actionable and resistant to standard treatments.

Epigenetic deprogramming driven by disruption of CIZ1-RNA nuclear assemblies in early-stage breast cancers

The paper shows that elevated CIZ1 C-terminal anchor domain in early-stage breast cancers disrupts nuclear RNA assemblies, leading to chromatin deprotection and gene expression changes.