NeuroscienceMolecular TherapyPeer-reviewed
Dendrimer Delivered shRNA Targeting the CCL20-CCR6 Axis Suppresses Complement-Mediated Microglial Synaptic Pruning and Ameliorates Chronic Neuroinflammation After Repetitive Traumatic Brain Injury
Karthick Mayilsamy, Parthvi Bharatkumar Patel, Ryan J. Green…·Subhra Mohapatra
This study identifies the CCL20-CCR6 axis as a driver of chronic neuroinflammation after rTBI and shows that shRNA targeting this axis reduces synaptic loss and improves behavioral outcomes.
DOI 10.1016/j.ymthe.2026.10.002