Dendrimer Delivered shRNA Targeting the CCL20-CCR6 Axis Suppresses Complement-Mediated Microglial Synaptic Pruning and Ameliorates Chronic Neuroinflammation After Repetitive Traumatic Brain Injury
Karthick Mayilsamy, Parthvi Bharatkumar Patel, Ryan J. Green, Sashank Bikkasani, Kristina Tosi, Shreyasi Majumdar, Santosh Kumar Prajapati, Eleni Markoutsa, Tiara Wolf, Jennifer Guergues, Stanley M. Stevens, Allison Willing, Shyam Mohapatra, Subhra Mohapatra
This study identifies the CCL20-CCR6 axis as a driver of chronic neuroinflammation after rTBI and shows that shRNA targeting this axis reduces synaptic loss and improves behavioral outcomes.
Molecular Therapy · Oct 1, 2026Peer-reviewedNeuroscience