KSHV upregulates the long non-coding RNA PURPL via p73 to suppress p53
Samia Showgan, Diana Meary, Guy Journo…·Meir Shamay
This study shows KSHV upregulates the oncogenic lncRNA PURPL through p73 to suppress p53, promoting PEL cell proliferation.
Author
Bar-Ilan UniversityORCID 0000-0003-0223-2852Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Samia Showgan, Diana Meary, Guy Journo…·Meir Shamay
This study shows KSHV upregulates the oncogenic lncRNA PURPL through p73 to suppress p53, promoting PEL cell proliferation.
Supriya Bhattacharya, Nilabja Roy Chowdhury, Anuj Ahuja…·Meir Shamay
This study shows that LINE-1 retrotransposons are upregulated in KSHV-infected cells and their knockdown impairs proliferation and alters gene expression.
Sandy Boutros‐Suleiman, Kavya Nambiar, Pooja Anil Shah…·Michael Blank
This study identifies SMURF2 and USP7 as regulators of KAP1 ubiquitination, showing that this dynamic cycle controls KAP1's SUMOylation activity and impacts chromatin structure and cancer progression.
Nilabja Roy Chowdhury, Vyacheslav Gurevich, Meir Shamay
This study identifies constitutive and lytically induced enhancers in the KSHV genome using functional assays and CRISPR techniques, revealing a 'viral super-enhancer' that regulates latency-to-lytic transition.