Author

Jacob T. Cain

Sanford ResearchORCID 0000-0003-0230-9979Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Jacob T. Cain1 paper

Biology Disciplines

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Neuroscience· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:behavioral assay· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1 Approach:statistical model· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Jill M. WeimeriD· 3 shared Jon J. BrudvigiD· 3 shared Tyler B. JohnsoniD· 3 shared Brandon L. MeyerinkiD· 2 shared Katherine A. WhiteiD· 2 shared Antti Nurmi· 1 shared Clarissa D. Booth· 1 shared Danielle G. MayiD· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersNeuroscience

Jill M. WeimerORCID

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3 papers

Recent·Most cited

NeuroscienceFrontiers in NeurosciencePeer-reviewedMay 25, 2022

Transmembrane Batten disease proteins interact with a shared network of vesicle sorting proteins to regulate synaptic composition and function.

Mitchell J. Rechtzigel, Brandon L. Meyerink, Hannah G. Leppert…·Jill M. Weimer

This study identifies a shared protein network involving Batten disease proteins that regulates synaptic composition and function through interactions with vesicle sorting proteins.

11 citations

𝕏 PostBluesky

NeuroscienceMolecular TherapyPeer-reviewedSep 24, 2020

AAV9 gene therapy restores lifespan and treats pathological and behavioral abnormalities in a mouse model of CLN8-Batten disease

Tyler B. Johnson, Katherine A. White, Jon J. Brudvig…·Jill M. Weimer

This study shows that AAV9 gene therapy in a mouse model of CLN8-Batten disease improves lifespan, reduces pathology, and reverses behavioral issues.

39 citations

mouseexperimental assay

𝕏 PostBluesky

PathologybioRxivPreprintJan 17, 2019

A multimodal approach to identify clinically relevant parameters to monitor disease progression in a preclinical model of neuropediatric disease

Tyler B. Johnson, Jon J. Brudvig, Kimmo K. Lehtimäki…·Jill M. Weimer

The paper uses a multimodal approach to identify clinically relevant parameters for tracking disease progression in a mouse model of Batten disease.

DOI 10.1101/522011

𝕏 PostBluesky