Pengfei Tian

GuideFlip co-designs protein structure and sequence for flexible targets, improving in silico success rates and experimentally validating binders to disordered proteins.

The paper screens bacterial cutinases to identify those with PET hydrolysis activity, finding it rare and mostly within the canonical-fold family.

The paper curates a benchmark dataset for exploring protein fitness landscapes using wildtype sequences and evaluates different representation paradigms for their predictive power.

This paper evaluates how different performance metrics and generalization definitions affect the assessment of protein regression models.