Christopher G. Tate

De novo design of flexible protein interactions with GuideFlip

GuideFlip co-designs protein structure and sequence for flexible targets, improving in silico success rates and experimentally validating binders to disordered proteins.

Molecular Architecture of the Human GCN1-ABCF3 Ribosome Collision Sensor

This study identifies ABCF3 as the mammalian ortholog of yeast Gcn20, which is recruited to ribosomes during amino acid starvation and interacts with GCN1 to activate Gcn2.

Insights from aquaporin structures into drug-resistant sleeping sickness

This study determines the structure of TbAQP2 bound to drugs and glycerol, revealing how mutations in the channel lead to drug resistance in Trypanosoma brucei.

Structure of the Gq-coupled adhesion receptor ADGRL4, a GPCR implicated in cancer

The paper determines the cryo-EM structure of ADGRL4 coupled to Gq, showing weak Gq coupling and distinct interactions compared to other GPCRs, supporting its role in cancer.

UDP-glucose Activation of a G-protein/Sucrose Synthase Signaling Supercomplex

This study identifies UDP-glucose as a signaling molecule that activates RGS1 to trigger G protein activation and modulate plant defense responses.

De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors

This paper presents computational methods for designing GPCR-binding miniproteins and validates them through high-throughput screening, producing agonists and antagonists for multiple GPCRs.

Molecular recognition of an aversive odorant by the murine trace amine-associated receptor TAAR7f

The paper determines the cryo-EM structure of mTAAR7f bound to DMCH, revealing its unique binding site and activation mechanism distinct from ORs.

Molecular determinants of β-arrestin coupling to formoterol-bound β1-adrenoceptor

This paper determines the cryo-EM structure of the β1AR-βarr1 complex bound to formoterol and compares it to the β1AR-Gs complex, revealing structural differences that inform biased agonism.