Fawzy Mohamed

The paper evaluates variant effect predictors and disease mechanisms in intrinsically disordered proteins, finding reduced sensitivity for pathogenic variants in these regions and highlighting the need for disorder-informed prediction strategies.

This study evaluates 35 variant effect predictors across 963 human genes, finding gene-level performance variability and identifying intrinsic disorder as a key factor affecting AUROC metrics.

The paper investigates the association of rare loss-of-function variants in type I IFN immunity genes with severe COVID-19 and finds no significant association.