Mapping galectin-3 ligands in tear fluid establishes spliceoform-dependent lacritin binding
Vincent Hung-Shu Chang, Isaac Lian, Keira E. Mahoney, Jeff Romano, Ali Reza Afshari, Ryan J. Chen, Xiangjun Chen, Fredrik Andreas Fineide, Ayyad Zartasht Khan, Tor Paaske Utheim, Niclas G. Karlsson, Gordon W. Laurie, Stacy Alyse Malaker
This study identifies new Gal-3 ligands in tear fluid, showing that lacritin's glycoforms and spliceoforms specifically bind Gal-3, influencing its biological functions.
bioRxiv · Nov 24, 2025 · PreprintBiochemistry