Author

Brianna Hnath

Pennsylvania State UniversityORCID 0000-0003-0342-4522Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

Nikolay V. DokholyaniD· 3 shared Congzhou Mike ShaiD· 1 shared Esther Sue ChoiiD· 1 shared Srinivasan EkambaramiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 4 mutual co-author links

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3 shared papersMolecular Biology

Nikolay V. DokholyanORCID

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3 papers

Recent·Most cited

Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers

Brianna Hnath, Srinivasan Ekambaram, Nikolay V. Dokholyan

The paper investigates how toxic SOD1 oligomers affect extracellular vesicle release pathways in ALS, identifying key proteins and pathways involved.

Neurobiology of Disease · Feb 5, 2026Peer-reviewedMolecular Biology

Unveiling the double-edged sword: SOD1 trimers possess tissue-selective toxicity and bind septin-7 in motor neuron-like cells

Esther Sue Choi, Brianna Hnath, Congzhou Mike Sha, Nikolay V. Dokholyan

This paper identifies tissue-selective toxicity of SOD1 trimers and their interaction with septin-7 in motor neuron-like cells, revealing pathways linked to ALS pathophysiology.

Structure · Aug 28, 2024Peer-reviewedNeuroscience

Toxic SOD1 trimers are off-pathway in the formation of amyloid-like fibrils in ALS

Brianna Hnath, Nikolay V. Dokholyan

This study shows that toxic SOD1 trimers are an off-pathway intermediate competing with protective fibril formation in ALS, and stabilizing trimers reduces larger aggregate formation.

Biophysical Journal · May 3, 2022Peer-reviewedMolecular Biology