GeneticsbioRxivPreprint
Slope-Hunter: A robust method for index-event bias correction in genome-wide association studies of subsequent traits
Osama Mahmoud, Frank Dudbridge, George Davey Smith…·Kate M. Tilling
Slope-Hunter corrects index-event bias in GWAS of subsequent traits by identifying and adjusting for genetic variants affecting only incidence, improving statistical performance in the presence of genetic correlation.