Author

Tim Holland-Letz

German Cancer Research CenterORCID 0000-0003-0348-8163Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:genome assembly· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Aldo QuattroneiD· 1 shared Alessandro DaducciiD· 1 shared Alessia SaricaiD· 1 shared Alexander LeemansiD· 1 shared ALI RAZA KHANiD· 1 shared Alia Lemkaddem· 1 shared Anna Auría· 1 shared Anneriet M. Heemskerk· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperNeuroscience

Aldo QuattroneORCID

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2 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintMar 4, 2026

Too rare to be random: genetic finding suggests previously unrecognized path of mutagenesis

Jonas Bohnlein, Johann Georg Maaß, Julia Dennig…·Christian Patrick Schaaf

The paper identifies a new genotypic configuration in twins with neurodevelopmental disorder, suggesting a previously unrecognized mutagenesis pathway.

DOI 10.64898/2026.03.03.26346966

humanwhole-genome sequencing

𝕏 PostBluesky

NeuroscienceNature CommunicationsPeer-reviewedNov 1, 2017

Tractography-based connectomes are dominated by false-positive connections

Klaus Hermann Maier-Hein, Peter Neher, Jean‐Christophe Houde…·Maxime Descoteaux

The paper evaluates tractography methods by analyzing a simulated dataset, finding that most algorithms generate many false-positive connections.

1,341 citationstop 1%

humanstatistical model

𝕏 PostBluesky