Maxime Descoteaux

Automated Segmentation and Tractography of Brainstem and Subcortical White Matter

The paper develops an automated pipeline for segmenting and parcellating brainstem and subcortical white matter pathways using diffusion MRI data.

Tractography from Serial Optical Coherence Tomography: How and Why?

This paper develops a method for microscale white matter tractography using S-OCT and validates it on simulated and mouse brain data, showing improved ODF estimation and tractography performance.

Connectome-based spatial statistics enabling large-scale population analyses of human connectome across cohorts

This paper introduces CBSS, a framework for analyzing structural connectomes across multiple cohorts, showing its reliability and utility in cross-cohort diffusion MRI studies.

Regional brain age deviations reveal divergent developmental pathways in youth

The paper uses brain age gaps to identify developmental trajectories in youth, finding distinct patterns in ADHD and cognitive profiles.

sf-pediatric: A robust and age-adaptable end-to-end pipeline for pediatric diffusion MRI

sf-pediatric provides an age-adaptable dMRI pipeline for pediatric studies, improving modeling and reproducibility across brain development.

Longitudinal functional connectivity during rest and task is differentially related to Alzheimer's pathology and episodic memory in older adults

The paper examines how changes in functional connectivity during rest and task relate to Alzheimer's pathology and episodic memory in older adults.

End-to-end evaluation of white matter microstructure of the visual pathway in asymmetric glaucoma

This study evaluates white matter microstructure in asymmetric glaucoma using advanced diffusion MRI methods, finding significant diffusion metric differences and correlations with clinical parameters.

White matter geometry confounds Diffusion Tensor Imaging Along Perivascular Space (DTI-ALPS) measures

Radial diffusivity asymmetry driving DTI-ALPS indices pervades white matter, persists at high b-values, and tracks crossing fibers, axonal undulation and dispersion rather than perivascular diffusion.

Mapping caudolenticular gray matter bridges in the human brain striatum through diffusion magnetic resonance imaging and tractography

This study introduces a novel tractography method to reconstruct and analyze caudolenticular gray matter bridges in the human brain using diffusion MRI, demonstrating their microstructural properties.

Body size interacts with the structure of the central nervous system: A multi-center in vivo neuroimaging study

This study shows body size parameters significantly correlate with brain and spinal cord MRI metrics and should be included in neuroimaging studies.

Data-driven characterization and correction of the orientation dependence of magnetization transfer measures using diffusion MRI

The paper characterizes and corrects orientation dependence in magnetization transfer measures using diffusion MRI data from 20 subjects.

High-frequency longitudinal white matter diffusion- & myelin-based MRI database: reliability and variability

The paper evaluates the reliability and variability of diffusion- and myelin-based MRI measurements across multiple sessions and fiber populations, finding moderate to high reliability for diffusion measures and bundle-dependent variability.

A Unified Filtering Method for Estimating Asymmetric Orientation Distribution Functions: Where and How Asymmetry Occurs in the Brain

This paper introduces a unified filtering method for estimating asymmetric ODFs in dMRI, showing it can detect complex asymmetric fiber configurations in brain data.

TractoInferno: A large-scale, open-source, multi-site database for machine learning dMRI tractography

TractoInferno provides a large-scale, multi-site database for benchmarking machine learning tractography methods using standardized data and evaluation protocols.

The length of the thalamo-cortical white matter fibers brings insight into sex differences in sleep spindle frequency

An atlas of white matter anatomy, its variability, and reproducibility based on Constrained Spherical Deconvolution of diffusion MRI

This paper presents a white matter atlas using probabilistic constrained-spherical deconvolution tractography, showing variability and reproducibility across datasets.

Prevalence of white matter pathways coming into a single diffusion MRI voxel orientation: the bottleneck issue in tractography

This study quantifies the prevalence of bottleneck regions in white matter where multiple fiber populations share the same orientation, showing over 50-70% of fixels are affected, leading to potential errors in tractography.

mrHARDIflow : A pipeline tailored for the preprocessing and analysis of Multi-Resolution High Angular diffusion MRI and its application to a variability study of the PRIME-DE database

The paper introduces mrHARDIflow, a pipeline for preprocessing and analyzing multi-resolution diffusion MRI data, and applies it to study variability in the PRIME-DE database.

Track-To-Learn: A general framework for tractography with deep reinforcement learning

Track-To-Learn uses deep reinforcement learning to improve diffusion MRI tractography without requiring labeled data, achieving better generalization than prior methods.

Enabling constrained spherical deconvolution and diffusional variance decomposition with tensor-valued diffusion MRI

This paper develops a tensor-valued constrained spherical deconvolution method and evaluates its performance on simulated and in vivo data for improved fiber orientation and microstructural measures.

Structural connectome fingerprinting and age prediction in pediatric development: assessing voxel- and surface-based white matter connectivity

The paper compares voxel- and surface-based methods for generating structural connectomes, finding voxel-based methods marginally better for age prediction and individual representation.

Processing the diffusion-weighted magnetic resonance imaging of the PING dataset

This paper processes diffusion-weighted MRI data from the PING dataset to improve connectomic analysis through advanced diffusion metrics and multimodal integration.

Diffusion MRI free water is a sensitive marker of age-related changes in the cingulum

This study shows that free water elimination improves the detection of age-related cingulum changes linked to verbal fluency decline in elderly individuals.

Pandora: 4-D white matter bundle population-based atlasesderived from diffusion MRI fiber tractography

The paper presents a population-based white matter atlas derived from diffusion MRI fiber tractography, including 216 bundles from 2443 subjects.

Bundle-specific associations between white matter microstructure and Aβ and tau pathology at their connecting cortical endpoints in older adults at risk of Alzheimer's disease

The paper examines associations between white matter microstructure and Aβ/tau pathology in specific brain bundles in at-risk older adults, finding diffusion metrics linked to Aβ and tau levels at cortical endpoints.

TractoFlow-ABS (Atlas-Based Segmentation)

TractoFlow-ABS improves tractography in pathological brains by using an atlas-based segmentation approach to avoid white matter mask holes caused by lesions.

Surface-Based Connectivity Integration

This paper introduces a framework called surface-based connectivity integration (SBCI) to analyze structural and functional brain connectivity by using the white surface and shows it creates reproducible biomarkers reflecting SC-FC similarity.

TractoFlow: A robust, efficient and reproducible diffusion MRI pipeline leveraging Nextflow & Singularity

TractoFlow is a diffusion MRI pipeline that ensures reproducibility and efficiency using Nextflow and Singularity, achieving high reproducibility and processing large datasets quickly.

Structural abnormalities in thalamo-prefrontal tracks revealed by high angular resolution diffusion imaging predict working memory scores in concussed children

This study uses diffusion imaging to identify structural abnormalities in thalamo-prefrontal white matter tracks that correlate with working memory deficits in concussed children.

Free water in white matter differentiates MCI and AD from control subjects

The paper develops a free water (FW) processing pipeline to differentiate mild cognitive impairment (MCI) and Alzheimer's disease (AD) from controls using diffusion MRI data.