Aldo Quattrone

Non-neuronal, TGF-β- extracellular matrix restructuring promotes neurodegeneration in a PSP-Richardson syndrome model

The paper identifies TGF-β-driven extracellular matrix remodeling in vascular leptomeningeal-like cells as a driver of neurodegeneration in PSP-RS, showing therapeutic potential through pharmacological inhibition.

Mosaic midbrain organoids: a new tool to study Progressive Supranuclear Palsy and advancing clinical neurology research

The paper introduces a novel iPSC-derived mosaic midbrain organoid system to model PSP-RS and demonstrates its ability to recapitulate key pathological features of the disease.

Insights from the IronTract challenge: optimal methods for mapping brain pathways from multi-shell diffusion MRI

The paper evaluates tractography methods using a macaque dataset to determine optimal approaches for mapping brain pathways from multi-shell diffusion MRI.

Small effect size leads to reproducibility failure in resting-state fMRI studies

This paper shows that small effect sizes in resting-state fMRI studies lead to reproducibility issues, even after multiple comparison corrections, and recommends meta-analysis of un-thresholded data for better results.

Tractography-based connectomes are dominated by false-positive connections

The paper evaluates tractography methods by analyzing a simulated dataset, finding that most algorithms generate many false-positive connections.