Mutation profiling of KRAS and BRAF in primary tumors and circulating tumor cells of colorectal cancer patients using PNA-LNA molecular switch
Md. Sajedul Islam, Eliza Ranjit, Sharmin Aktar, Neda Moetamedirad, Cu‐Tai Lu, Muhammad J. A. Shiddiky, Vinod Gopalan, Alfred King-yin Lam
This study uses the PNA-LNA molecular switch to detect KRAS and BRAF mutations in CRC tumors and CTCs, finding significant correlations between KRAS mutations in CTCs and clinicopathological features.
bioRxiv · Jun 1, 2025 · PreprintCancer Biology