Genetic & Genomic MedicinemedRxivPreprint
Recalibrating Mendelian randomization under winner's curse, sample structure and polygenicity
Yihe Yang, Zhaotong Lin, Haoran Xue, Xi Zhu
This paper introduces a multivariable Rao-Blackwellization method to correct Mendelian randomization biases from winner's curse, polygenicity, and sample structure, improving type-I error control and inference robustness.
DOI 10.64898/2026.06.25.26356593