BioinformaticsbioRxivPreprint
A Robust and Integrated Framework for Cross-platform Adaptation of Epigenetic Clocks in Cell-free DNA Sequencing
Guangyu Li, Weilai Huang, Xuechen Zhao…·Guangyu Zhou
The paper develops a framework to adapt epigenetic clocks to HTS-based cfDNA data, improving age prediction and clinical relevance through technical noise mitigation and transfer learning.
DOI 10.1101/2025.11.27.690895