Bin Hu

The paper develops a framework to adapt epigenetic clocks to HTS-based cfDNA data, improving age prediction and clinical relevance through technical noise mitigation and transfer learning.

The paper identifies cardiotoxic drug signatures using bulk transcriptomics and integrates them with genomic and single-cell data to predict toxicity mechanisms.

This study investigates the structural architecture of two SMC-kleisin complexes, revealing a folded conformation mediated by a dynamic coiled-coil discontinuity.

This study shows Scc2/4 maintains cohesin on chromosomes during G1 by blocking a Wapl-independent release mechanism, but is unnecessary during S phase for establishing cohesion.

The paper investigates how cohesin organizes DNA through both topological and non-topological mechanisms, showing that hinge domain mutations affect DNA entrapment and loading.

This study compares 3-DGE and conventional mRNAseq, finding similar gene expression results with 3-DGE offering cost savings and scalability.

The paper investigates how Scc1 and Scc2 interactions regulate cohesin's ATPase activity and displacement of Pds5 during loading.