Gregory Darnell

This paper introduces i-LDSC, an extension of LDSC that accounts for genetic interactions, showing it recovers additional genetic variance in 25 traits from UK Biobank and BioBank Japan.

This paper introduces BANNs, a probabilistic framework for GWA studies that improves association mapping and enrichment analysis by incorporating biological annotations and variational inference.

The paper develops ImageCCA to link histological image features with gene expression, identifying gene-morphology associations in TCGA and GTEx data.

The paper identifies epistatic genetic interactions in height and BMI using a novel region-based method across diverse UK Biobank subgroups, finding 245 enriched pathways with 67% in African ancestry.