Author

Valerio Piomponi

AREA Science ParkORCID 0000-0003-0433-8319Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:deep learning· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Research Focus:sequence-to-function modeling· 1 Approach:statistical model· 1

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Alberto CazzanigaiD· 1 shared Francesca CuturelloiD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperBioinformatics

Alberto CazzanigaORCID

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1 paper

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BioinformaticsbioRxivPreprintApr 8, 2025

Evolutionary constraints guide AlphaFold2 prediction of alternative conformations and inform rational mutation design

Valerio Piomponi, Alberto Cazzaniga, Francesca Cuturello

This paper improves AlphaFold2's ability to predict alternative protein conformations by integrating clustering strategies and evolutionary signals, enabling rational mutation design.

1 citation

protein structuredeep learning

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