Francesca Cuturello

The paper develops ESM3-PPISites, a model that identifies protein-protein interaction interfaces using multimodal representations, outperforming existing methods and improving docking accuracy.

This paper improves AlphaFold2's ability to predict alternative protein conformations by integrating clustering strategies and evolutionary signals, enabling rational mutation design.

The paper improves prediction of protein stability changes from single mutations using MSA-based language models and a curated dataset, achieving better performance than existing methods.

The paper introduces adversarial perturbations to protein sequences to disrupt 3D structure predictions, highlighting inconsistencies between mutation biological impact and model responses.

The paper analyzes the geometric properties of hidden representations in protein language models and identifies three distinct phases that reveal a general strategy for reconstructing missing data.