Developmental BiologyeLifePeer-reviewed
Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals
Amrita A. Iyer, Ishwar Hosamani, John D Nguyen…·Andrew K. Groves
This study shows that reprogramming mature mammalian cochlear cells with ATOH1, GFI1, and POU4F3 is hindered by epigenetic inaccessibility and cell-cell signaling, particularly Notch signaling.