Andrew J. Piasecki

The paper identifies age-related mitochondrial subpopulation changes in oocytes and cumulus cells and shows NMN has subpopulation-specific effects.

This study reanalyzes single-cell RNA sequencing data to show that mitochondrial gene expression changes precede oxidative phosphorylation activation and lineage specification in human pre-implantation embryos.

The paper identifies that Tead4 preferentially localizes to large, high-membrane-potential mitochondria in 8-cell embryos, establishing a mitochondrial basis for its bioavailability during early mammalian cell fate decisions.