Evolutionary BiologybioRxivPreprint
Weakest link epistasis and the geometry of genetic load
Florian Labourel, Florence Bansept, David M. McCandlish
The paper introduces weakest-link epistasis as a framework to analyze genetic load and shows how increasing phenotypic dimensionality affects fitness, comparing it to Fisher's geometric model.
DOI 10.64898/2025.12.08.693057