Toshiyuki Amagasa

Multiplying the AlphaFold 3 or Boltz-2 pair representation by a single scalar (1+β) at the Pairformer input, without retraining, broadens sampled ensembles toward alternative states across 86 two-state targets.

ConforFlux enhances protein structure prediction by sampling diverse conformations through trunk repulsion, improving success rates and coverage across multiple models and targets.