Paula García-Galindo

The paper compares Boltzmann distributions of natural and random non-coding RNA, finding natural RNA are slightly more stable, except for short sequences.

The paper analyzes the RNA genotype-phenotype map to show that phenotypic changes from point mutations can be abrupt, with robust sites producing larger phenotypic shifts when changes occur.

This study models RNA phenotypic plasticity using evolutionary simulations and shows that optimal plasticity emerges as an adaptive response to fluctuating environments.