Sebastian E. Ahnert

The paper compares Boltzmann distributions of natural and random non-coding RNA, finding natural RNA are slightly more stable, except for short sequences.

The paper characterizes the robustness and complexity of a protein secondary structure genotype-to-phenotype map using a plant pathogen effector domain.

FlowFI is an open-source software tool for designing and refining imaging parameters in flow cytometry to improve the analysis of rare cell populations like bone marrow megakaryocytes.

This study introduces a computational pipeline using secondary structure elements to detect protein symmetry and structural rearrangements, identifying 17,130 circularly related proteins and 26,739 proteins with indel mutations.

The paper analyzes the RNA genotype-phenotype map to show that phenotypic changes from point mutations can be abrupt, with robust sites producing larger phenotypic shifts when changes occur.

This paper introduces a method to identify proteins with identical topology but different conformations from the PDB, enabling the study of large-scale structural dynamics.

This paper introduces a fast method to predict protein contact maps from sequences, achieving high accuracy in 110 milliseconds.

The paper constructs a genotype-phenotype map for influenza hemagglutinin using predicted secondary structure, revealing local neutrality and limited structural evolvability.

The paper introduces an entropic measure to identify multifunctional neurons by combining topological analysis with node metadata in connectomes of C. elegans and Drosophila.

The paper investigates how changes in miRNA secondary structure predict disease-associated mutations by analyzing computational predictions and comparing them to a database of known mutations.

The paper introduces a compact representation of protein structures called Secondary Structure Elements (SSEs) that enable fast and accurate structure searching with performance comparable to Foldseek.

This study models RNA phenotypic plasticity using evolutionary simulations and shows that optimal plasticity emerges as an adaptive response to fluctuating environments.

The paper systematically annotates a complete adult male Drosophila nerve cord connectome, identifying neuron types, connectivity patterns, and sensory modalities to reveal organizational principles.

The paper shows duplication accelerates structural complexity in protein quaternary structures through in silico simulations and analysis of the Protein Data Bank.