Pharmacology & ToxicologybioRxivPreprint
Cryo-EM reveals a new allosteric binding site at the M5 mAChR
Wessel A. C. Burger, Jesse I. Mobbs, Bhavika Rana…·David M. Thal
The paper presents a cryo-EM structure of the M5 mAChR with a novel allosteric binding site identified through mutagenesis, pharmacology, and simulations.