Author
Australian Research CouncilORCID 0000-0002-2509-7465Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
4 papers
Recent·Most cited
Jesse I. Mobbs, M. Deborah Nguyen, Owindeep Deo…·David M. Thal
The paper presents cryo-EM structures of the delta opioid receptor with PAMs, identifies a novel allosteric site, and describes a mechanism for enhanced binding and activation.
Michaela G. Kaoullas, Jesse I. Mobbs, Ziva Vuckovic…·David M. Thal
This paper reports the cryo-EM structure of the M4 mAChR bound to MK-97 and acetylcholine, revealing how MK-97's binding mode improves PAM activity through distributed interactions.
Wessel A. C. Burger, Jesse I. Mobbs, Bhavika Rana…·David M. Thal
The paper presents a cryo-EM structure of the M5 mAChR with a novel allosteric binding site identified through mutagenesis, pharmacology, and simulations.
Wessel A. C. Burger, Christopher J. Draper-Joyce, Céline Valant…·David M. Thal
This study shows positive allosteric modulators stabilize the GPCR-G protein ternary complex, enhancing signaling when nucleotides are present.