Uberto Pozzoli

KDM provides a unified framework for motif discovery, analysis, and binding prediction by embedding DNA/RNA sequences and motifs in a shared k-mer space using the Hellinger transformation and Bhattacharyya coefficient.

RNAMaRs infers RNA motifs and their regulatory proteins by integrating motif discovery, binding data, and splicing responses, showing consistent prioritization of perturbed regulators in ENCODE datasets.

The paper analyzes mutations in hMPXV1 genomes to identify clustering patterns and sequence context, suggesting APOBEC-mediated editing as the mutational mechanism.