A forward genetic screen identifies Sirtuin1 as a driver of neuroendocrine prostate cancer
Francisca Nunes de Almeida, Alessandro Vasciaveo, Arianna Giacobbe…·Cory T. Abate-Shen
The paper uses a forward genetic screen in a mouse model to identify Sirtuin1 as a driver of neuroendocrine prostate cancer, showing its role in promoting NEPC and potential as a therapeutic target.