Aleksandar Obradović

This study identifies TMPO as a driver of CTC heterogeneity and metastasis in prostate cancer by enhancing survival under metabolic stress.

The paper compares early-onset and late-onset colorectal cancer using scRNA-seq and VIPER to identify distinct stromal and epithelial features in early-onset tumors.

The paper uses single-cell analysis to study how cell surface antigen expression changes in treatment-resistant prostate cancer, revealing transcriptional heterogeneity and shared gene regulatory networks between NEPC and SCLC.

The paper identifies master regulator dependencies in coexisting diffuse midline glioma subpopulations and shows that combination therapy targeting these regulators improves survival in vivo.

The paper introduces PISCES, a platform that improves single-cell analysis by estimating protein activity's role in cell state, validated with experimental assays and applied to human tissue data.