The paper identifies POU6F2 as a marker for a novel group of ON-OFF directionally selective retinal ganglion cells that are sensitive to glaucomatous injury.

bioRxiv · Feb 28, 2020 · PreprintGenetics

Genomic Locus Modulating IOP in the BXD RI Mouse Strains

Rebecca King, Ying Li, Jiaxing Wang, Felix L. Struebing, Eldon E. Geisert

The paper identifies a genomic locus on chromosome 8 associated with intraocular pressure (IOP) regulation in BXD RI mouse strains, with Cdh11 as the most likely candidate gene.

G3 Genes Genomes Genetics · Mar 1, 2018Peer-reviewedGenetics

Genomic Loci Modulating Retinal Ganglion Cell Death Following Elevated IOP in the Mouse

Felix L. Struebing, Rebecca King, Ying Li, Jessica N. Cooke Bailey, Janey L. Wiggs, Eldon E. Geisert

This study identifies a genomic locus on Chromosome 18 associated with retinal ganglion cell loss in a mouse glaucoma model.

Experimental Eye Research · Feb 3, 2018Peer-reviewedGenetics

Genomic Locus Modulating Corneal Thickness in the Mouse Identifies POU6F2 as a Potential Risk of Developing Glaucoma

Rebecca King, Felix L. Struebing, Ying Li, Jiaxing Wang, Allison E. Ashley‐Koch, Jessica N. Cooke Bailey, Puya Gharahkhani, Stuart MacGregor, R. Rand Allingham, Michael A. Hauser, Janey L. Wiggs, Eldon E. Geisert

The paper identifies a genomic locus modulating corneal thickness in mice and links it to POU6F2, a potential risk factor for glaucoma.

PLoS Genetics · Jan 25, 2018Peer-reviewedGenetics

The BXD Mouse Strains are a Model System for Studying Optic Nerve Regeneration

Jiaxing Wang, Ying Li, Rebecca King, Felix L. Struebing, Eldon E. Geisert

This study shows that genetic background affects optic nerve regeneration, with BXD strains showing significant variation in axonal regrowth.

bioRxiv · Oct 30, 2017 · PreprintNeuroscience