Author

Yaser Heshmati

Boston Children's HospitalORCID 0000-0003-0963-2496Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:differential expression· 1

Frequent Co-Authors

Jazmin EwersiD· 3 shared Jérémie KalfoniD· 3 shared Kenneth EagleiD· 3 shared Kimberly StegmaieriD· 3 shared Maxim PimkiniD· 3 shared Monika W. PereziD· 3 shared Neekesh V. DhariaiD· 3 shared Stuart H. OrkiniD· 3 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Jazmin EwersORCID

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3 papers

Recent·Most cited

Systems BiologybioRxivPreprintMar 13, 2023

Leukemia core transcriptional circuitry is a sparsely interconnected hierarchy stabilized by incoherent feed-forward loops

Taku Harada, Jérémie Kalfon, Monika W. Perez…·Maxim Pimkin

The paper reconstructs a sparsely interconnected transcriptional hierarchy in leukemia cells stabilized by incoherent feed-forward loops and shows inhibitors disrupt core regulators' programs.

7 citations

humanbulk RNA-seq

𝕏 PostBluesky

GenomicsBlood Cancer DiscoveryPeer-reviewedJun 15, 2022

Transcriptional plasticity drives leukemia immune escape

Kenneth Eagle, Taku Harada, Jérémie Kalfon…·Maxim Pimkin

The paper identifies transcription factors regulating MHC-II expression in AML and shows their role in immune evasion and relapse.

21 citations

humanbulk RNA-seq

𝕏 PostBluesky

GenomicsGenes & DevelopmentPeer-reviewedMar 1, 2022

A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia

Taku Harada, Yaser Heshmati, Jérémie Kalfon…·Maxim Pimkin

The paper identifies a modular core regulatory circuitry in AML that enforces oncogene expression in KMT2A-rearranged leukemias.

31 citations

humanbulk RNA-seq

𝕏 PostBluesky