Christopher P. Long

Simultaneous application of enzyme and thermodynamic constraints to metabolic models using an updated Python implementation of GECKO

This paper updates geckopy to improve enzyme-constraint modeling by integrating proteomics data and thermodynamic constraints, benchmarking against E. coli datasets.

Laboratory evolution of multiple E. coli strains reveals unifying principles of adaptation but diversity in driving genotypes

This study uses multi-omics data from evolving E. coli strains to identify convergent and divergent adaptation principles at metabolic, transcriptomic, and genetic levels.