Maciek R. Antoniewicz

The Sensitivity of 13C-Metabolic Flux Analysis to Biomass Composition Underscores the Need for Accurate Biomass Formulation in Escherichia coli

This study shows that 13C-MFA in E. coli is sensitive to biomass composition, emphasizing the need for accurate biomass formulations in flux analysis.

Exchange of metabolic pathway intermediates as the origin for metabolite cross-feeding interactions in E. coli auxotrophic co-cultures

This study shows that histidinol exchange enables metabolite cross-feeding in E. coli auxotrophs under methionine limitation, supporting mutualistic interactions through pathway intermediate accumulation.

Exhaustive Isotope Tracing Reveals the Butterfly Effect of Mammalian Producer Cell Line Selection for Biomanufacturing

This study uses isotope tracing to compare metabolic differences between two CHO cell lines, revealing how cell line selection impacts metabolism and biomanufacturing.

Hydrogen sulfide dynamically upregulates copper uptake and localization

This study shows hydrogen sulfide increases copper uptake and localization in cells, with copper primarily in the Cu2+ state, using the ZNT1 transporter for import and ATP7A for export.

Accelerated osteocytic citrate production in chronic kidney disease is associated with protection of the kidney

This study shows that accelerated citrate production by osteocytes in CKD mice protects kidney function, suggesting citrate handling as a therapeutic target.

Laboratory evolution of multiple E. coli strains reveals unifying principles of adaptation but diversity in driving genotypes

This study uses multi-omics data from evolving E. coli strains to identify convergent and divergent adaptation principles at metabolic, transcriptomic, and genetic levels.